Fulfilling a promise to his deceased father, one-time outlaw Jesse Custer returns home to West Texas to take over his dad's church. Jesse's mission, however, becomes twisted when his body is overcome by a cryptic force that unleashes within him a highly unconventional power. Together with hell-raising ex-girlfriend Tulip and Irish vagabond Cassidy, the preacher-in-training embarks on a journey to find God in a world inhabited by holy, hellish, and everything-in-between characters.
When Texas preacher Jesse Custer is inhabited by the renegade spawn of an angel and a demon, he gains the power to control people with just a word. Now Jesse, his badass ex Tulip O'Hare, and his friend Cassidy (who happens to be a vampire) are thrust into a twisted battle spanning Heaven, Hell and everywhere in between.